左旋四氢帕马丁对条件线索诱导的大鼠海洛因复吸行为的影响

摘要

Objective To investigate the effects of levo-tetrahydropalmatine(l-THP)on conditioned cues-induced reinstatement of heroin-seeking behavior in rats. Methods Rats were trained to self-administer heroin under fixed ratio 1 schedule. Following withdrawal(l4 d) , rats received vehicle or l-THP treatment (ip. ) , and conditioned cues-induced heroin seeking behavior was recorded. Results As compared with vehicle,l-THP significantly decreased the number of active nose poke(P＜0. 05). Conclusion l-THP may reduce the propensity to resume conditioned cues-induced heroin seeking behavior,offering a possible approach in maintaining opiate abstinence.%目的 研究左旋四氢帕马丁(levo-tetrahydropalmatine,l-THP)对条件线索诱导的大鼠海洛因复吸行为的干预作用.方法 应用固定比率程序(fixed ratio,FR)1建立大鼠海洛因自身给药模型,戒断14 d后,观察l-THP对条件线索诱导的大鼠海洛因复吸行为的影响.结果 2 h内l-THP组大鼠有效鼻触次数显著低于溶媒对照组(P＜0.05).结论 l-THP能有效干预条件线索诱导的大鼠海洛因复吸行为,具有预防海洛因复吸的应用前景.