生物活性玻璃/聚乳酸组织工程支架在SBF溶液中的降解和矿化性能

摘要

The degradable performance and bio-mineralization function of bioglass/poly（lactic acid） tissue engineering scaffolds were systematically studied in the simulated body fluid（SBF） by measuring pH value of SBF,the loss mass rate of the scaffolds and analyzing SEM pictures,XRD and FTIR spectra of scaffolds＇ surface.It was found that in SBF,the pH value of SBF with bioglass/poly（lactic acid） tissue engineering scaffolds and the mass of bioglass/poly（lactic acid） scaffolds decreases with the prolongation of time.SEM pictures and XRD,FTIR spectra showed that there appears the deposition of carbonate hydroxyl apatite on the surface of the bioglass/poly（lactic acid） tissue engineering scaffolds.The result shows that the bioglass/poly（lactic acid） tissue engineering scaffolds have good bio-mineralization function.%利用扫描电镜、X衍射仪以及红外漫反射仪,并通过对生物活性玻璃/聚乳酸组织工程支架在模拟体液（SBF）中失重率及模拟体液pH值的变化的检测,系统研究了生物活性玻璃/聚乳酸组织工程支架在SBF中的降解和矿化性能。结果发现：随着含有生物活性玻璃的聚乳酸支架在SBF溶液中浸泡时间的增长,SBF的pH值不断下降;含有生物活性玻璃的聚乳酸支架的质量不断下降。XRD、FTIR谱图和SEM图像表明：在SBF中浸泡一定时间后,有无定型的或结晶不完善的磷灰石在含有生物活性玻璃的聚乳酸支架的表面沉积形成。