磺胺嘧啶银/聚乙烯醇水凝胶复合材料的制备及性能表征

摘要

A series of sulfadiazine Ag(SD-Ag)/polyvinyl alcohol(PVA)hydrogel composites were preparated by e-Beam irradiation combining with freeze-thawing.The influence of preparation process of polyvinyl alcohol (PVA) hydrogel on its properties was investigated.The tensile strength,elongation at break,water absorption,gel con-tent,morphologies of the surfaces and their relationships with the mass fraction of PVA and preparation process were characterized using tensile testing machine,SEM and FT-IR.The mechanical tests show that the tensile strength of PVA hydrogel increases with the mass fraction of PVA(5%-15%).When the mass fraction of PVA is 15%,and the irradiation doses is 25 kGy,the tensile strength of PVA hydrogel is 0.023 MPa,0.048 MPa, 0.028 MPa and the water absorption is 95%,45%,63%,by e-Beam irradiation alone,freeze-thawing after irradia-tion and irradiation after freeze-thawing,respectively,which indicate that e-Beam irradiation combining with freeze-thawing increases the tensile strength and decreses the water absorption of the PVA hydrogel.The antibacterial activ-ity of SD-Ag/PVA hydrogel was investigated after adding SD-Ag into the PVA hydrogel.The zones of inhibition show that the antibacterial activities can be enhanced with the mass fraction of SD-Ag increasing and that the composites have higher %采用e-Beam电子辐射和冻融循环相结合的方法制备了磺胺嘧啶银(SD-Ag)/聚乙烯醇(PVA)水凝胶.研究了制备工艺对PVA水凝胶的性能的影响.通过拉伸性能测试、吸水率检测、SEM和FT-IR等表征,考察了PVA浓度(占总质量5%~15%)、冻融与辐射处理等对PVA水凝胶拉伸强度、断裂伸长率、吸水性、凝胶含量和微观结构等的影响.结果表明:随着PVA浓度增大,PVA水凝胶的拉伸强度提高.当PVA浓度为15%、辐射剂量为25 kGy时,单独辐射、辐射后冻融及冻融后辐射三种工艺制备的PVA水凝胶拉伸强度分别为0.023 MPa、0.048 MPa、0.028 MPa,吸水率分别为为95%、45%、63%,说明经冻融处理的水凝胶力学强度提高,吸水率有所下降.然后,选择适当的制备工艺并在PVA水凝胶中加入SD-Ag,考察了SD-Ag/PVA水凝胶的抑菌性能,抑菌活性测试结果显示,随着SD-Ag含量的增加,SD-Ag/PVA水凝胶的抑菌效果增强,而且其对革兰式阴性菌(大肠杆菌)的抑菌效果优于其对革兰式阳性菌(金黄色葡萄球菌)的抑菌效果.