PROTEIN KINASES AND CENTRAL SENSITIZATION OF SPINAL DORSAL HORN NEURONS:CENTRAL MECHANISMS OF PAIN

摘要

@@ The enhanced responsiveness of spinal dorsal horn neurons, including spinothalamic tract (STT) cells, that follows peripheral tissue injury or inflammation is thought to underlie the development of secondary hyperalgesia and allodynia and is referred to as "central sensitization" because the increases in excitability do not appear to depend on continued activity of peripheral nociceptors.