Objective To evaluate the association of Prol2 Ala polymorphism of peroxisome prolifera-tor activated receptor γ (PPARγ) wordsγ ) gene with type 2 diabetes (T2DM) in Chinese Han population. MethodsThe present investigation was carried out using the keywords "PPAR7" , "pparg" , "Prol2Ala", "type 2diabetes" , and " Chinese. The odds ratios (OR) for Alal2 used as the metric of choice were calculated in thedominant and additive model separately. The Meta-analysis was conducted by softeware STATA 11.0. Results(1) We identified 22 studies, of which 17 studies involving 3927 type 2 diabetes cases and 3364 controlsfell into the inclusion criteria. The analysis indicated no significant inter-study heterogeneity and publicationbias. (2) The frequencies of the minor allele Alal2 in type 2 diabetes and control groups were 4. 8% and 4. 6% respectively. (3 ) The combined overall OR of dominant and additive model calculated by fix-effects me-ta-analysis for type 2 diabetes and the Prol2Ala polymorphism, were 0.95 (95% C/:P: 0.80, 1. 12) and 0.93 (95% CI; 0.79, 1.09) respectively. Conclusion In this meta-analysis, the Prol2Ala gene variant (rsl801282) is not found to be associated with the susceptibility for type 2 diabetes in Chinese Han population.%目的 评价中国汉族人群过氧化物酶体增殖物激活受体γ(PPARγ)基因多态性Pro12Ala与2型糖尿病的相关性.方法 以“PPARγ”、“pparg”、“Pro12Ala”、“type 2 diabetes”、“Chinese”、“过氧化物酶增殖剂激活受体”、“2型糖尿病”为检索词,全面检索2型糖尿病与Pro12Ala相关的文献,用stata 11.0进行Meta分析,对研究数据的优势比(OR)值进行合并,并评价分析结果的可靠性和稳定性.结果(1)检索到22篇,其中17篇符合纳入标准,包含了3927例2型糖尿患者和3364例正常对照,共7921名.纳入研究人群同质性较好,无显著发表偏倚.(2)次要等位基因Ala12在正常人和2型糖尿病患者中的频率分别为4.8％与4.6％.在显性和加性遗传模式下,次要等位基因携带者相对于未携带者的OR值分别为0.95(95％ CI:0.80,1.12)和0.93(95％ CI:0.79,1.09).结论 中国汉族人群PPARγ基因多态性Pro12Ala与2型糖尿病无相关性.
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