趋化素样因子超家族成员5研究进展

摘要

趋化素样因子超家族(CMTM)是北京大学人类疾病基因研究中心在国际上首次报道的新基因家族,CMTM5是该家族成员,其基因编码产物具有潜在的四次跨膜蛋白结构,是一个新的肿瘤抑制基因.研究表明,CMTM5广泛表达于人类正常组织,在大多数肿瘤细胞系和组织中表达明显下调或不表达,恢复其表达可抑制肿瘤细胞的增殖、黏附和迁移等生物行为.CMTM5抗肿瘤活性的机制尚不明确,可能参与了多个与癌症发生发展密切相关的信号通路.对CMTM5与肿瘤发生发展机制的进一步研究具有重要意义,其有望成为肿瘤基因治疗的新靶标.%CKLF-like MARVEL transmembrane domain containing member (CMTM) is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM5 belongs to this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily (TM4SF). CMTM5 is broadly expressed in normal adult and fetal human tissues, but is undetect-able or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM5 may inhibit the proliferation , migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CMTM5 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM5 may be a new target in the gene therapies for tumors, while further studies on CMTM5 and its anti-tumor mechanisms are warranted.