Synthesis and characterization of biodegradable polyurethane based on poly(ε-caprolactone) and L-lysine ethyl ester diisocyanate

摘要

A biocompatible diisocyanate, lysine ethyl ester diisocyanate, was prepared. Afterwards, biodegra-dable polyurethane (PU) was synthesized by the step-growth polymerization of this diisocyanate with hydroxyl terminated poly(ε-caprolactone) in the presence of 1,4-butanediol as a chain-extender. The resulting PU was characterized by GPC, IR and DSC measurements. Its mechanical strength was found to increase with increasing the hard segment content. The PU microfiber meshes with high porosity were obtained by solution electrospinning technique. Their degradation behavior in the PBS and enzymatic solution was also investigated.