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Molecular Basis of Class Ib Drug Interactions with the NaV Channel Macromolecular Complex: A Route to Personalized Medicine for Cardiac Arrhythmia

机译：IB类药物与NAV通道大分子复合物的分子基础：用于心脏心律失常的个性化药物的途径

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作者
Zhu, Wandi.;
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作者单位

Washington University in St. Louis.;

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授予单位 Washington University in St. Louis.;
学科
学位 Ph.D.
年度 2018
页码 123 p.
总页数 123
原文格式 PDF
正文语种 eng
中图分类 AAI10982115;
关键词
Antiarrhythmic; Arrhythmia; Ion channel;

机译：抗心律不整;心律失常;离子通道;

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专利

1. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. [J] . Petitprez S, Zmoos AF, Ogrodnik J, Circulation research: a journal of the American Heart Association . 2011,第3期

机译：SAP97和肌营养不良蛋白大分子复合物决定了心肌细胞中两个钠通道Nav1.5的合并。
2. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. [J] . Norelle C Wildburger, Syed R Ali, Wei-Chun J Hsu, Molecular & cellular proteomics: MCP . 2015,第5期

机译：定量蛋白质组学揭示了与成纤维细胞生长因子12作为哺乳动物大脑中电压门控钠通道1.2（nav1.2）大分子复合物的组成部分的蛋白质-蛋白质相互作用。
3. Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia [J] . Michelle L. Milstein, Hassan Musa, Daniela Ponce Balbuena, Proceedings of the National Academy of Sciences of the United States of America . 2012,第31期

机译：大分子复合物中钠和钾通道表达的动态可逆性控制心脏兴奋性和心律不齐
4. Drug-free macromolecular therapeutics - a new paradigm in nanomedicines [C] . Jane Yang, Te-Wei Chu, Jonathan M Hartley, World biomaterials congress . 2016

机译：无药物大分子疗法-纳米药物的新范例
5. Use of molecular modeling tools in the elucidation of ligand -macromolecular interactions and applications in structure -based drug design [D] . Mukherjee, Prasenjit 2008

机译：分子建模工具在阐明配体-大分子相互作用中的应用及其在基于结构的药物设计中的应用
6. Quantitative Proteomics Reveals Protein–Protein Interactions with Fibroblast Growth Factor 12 as a Component of the Voltage-Gated Sodium Channel 1.2 (Nav1.2) Macromolecular Complex in Mammalian Brain [O] . Norelle C. Wildburger, Syed R. Ali, Wei-Chun J. Hsu, 2015

机译：定量蛋白质组学揭示了成纤维细胞生长因子12作为哺乳动物大脑中电压门控钠通道1.2（Nav1.2）大分子复合物的组成部分与蛋白质-蛋白质的相互作用。
7. SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes [O] . Petitprez, Séverine, Zmoos, Anne-Flore, Ogrodnik, Jakob, 2011

机译：SAP97和肌营养不良蛋白大分子复合物决定了心肌细胞中两个钠通道Nav1.5的合并
8. Complexity Measure Revisited: A New Algorithm for Classifying Cardiac Arrhythmias. [R] . Ayesta, U., Serrano, L., Romero, I. 2001

机译：复杂度测量再探：一种新的心律失常分类算法。

Molecular Basis of Class Ib Drug Interactions with the NaV Channel Macromolecular Complex: A Route to Personalized Medicine for Cardiac Arrhythmia

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