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Bacterial phenylalanine hydroxylase: Cloning, preparation, structural features, steady-state mechanism, and preliminary investigation of active -site residues

机译：细菌苯丙氨酸羟化酶：活性位点的克隆，制备，结构特征，稳态机制和初步研究

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作者
Volner, Alon;
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作者单位

University of California Los Angeles;

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授予单位 University of California Los Angeles;
学科
学位 Ph.D.
年度 2003
页码 121 p.
总页数 121
原文格式 PDF
正文语种 eng
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专利

1. The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase [J] . Miranda FF, Kolberg M, Andersson KK, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2005,第6期

机译：活性位点残基酪氨酸325影响人苯丙氨酸羟化酶中的铁结合和偶联效率
2. Phenylalanine residues in the active site of tyrosine hydroxylase: mutagenesis of Phe300 and Phe309 to alanine and metal ion-catalyzed hydroxylation of Phe300. [J] . Ellis HR, Daubner SC, McCulloch RI, Biochemistry . 1999,第34期

机译：酪氨酸羟化酶活性位点中的苯丙氨酸残基：Phe300和Phe309诱变为丙氨酸和金属离子催化的Phe300羟基化。
3. Characterization of phenylketonuria missense substitutions, distant from the phenylalanine hydroxylase active site, illustrates a paradigm for mechanism and potential modulation of phenotype. [J] . Waters PJ, Parniak MA, Akerman BR, Molecular genetics and metabolism . 2000,第2期

机译：远离苯丙氨酸羟化酶活性位点的苯丙酮尿症错义取代的表征说明了表型机制和潜在调节的范例。
4. FT-ICR-MASS SPECTROMETRIC ANALYSIS OF POLYKETIDE BIOSYNTHESIS: PRELIMINARY STEADY-STATE AND TRANSIENT KINETICS OF ACTIVE-SITE BOUND INTERMEDIATES [C] . Christopher M. Rath, David H. Sherman, Kristina Hakansson ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：聚酮化合物生物合成的FT-ICR质谱分析：初步稳态和瞬态动力学的活性位点中间体
5. Investigation of the active site structure of non-heme iron dependent phenylalanine hydroxylase: Spectroscopic studies and their implications for reaction mechanism. [D] . Mitic, Natasa. 2001

机译：非血红素依赖铁的苯丙氨酸羟化酶活性位点结构的研究：光谱研究及其对反应机理的影响。
6. Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55 (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine. [O] . A Hädener, P R Alefounder, G J Hart, 1990

机译：羟甲基胆碱合酶中假定的活性位点赖氨酸残基的研究。突变体的制备和表征其中（a）Lys-55（b）Lys-59和（c）Lys-55和Lys-59均已被谷氨酰胺替代。
7. The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase [O] . Miranda Frederico F., Kolberg Matthias, Andersson K. Kristoffer, 2005

机译：活性位点残基酪氨酸325影响人苯丙氨酸羟化酶中的铁结合和偶联效率

Bacterial phenylalanine hydroxylase: Cloning, preparation, structural features, steady-state mechanism, and preliminary investigation of active -site residues

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