Electronic mosquito: A feedback-controlled semi-invasive microsystem for glucose monitoring.

摘要

The increasing prevalence of diabetes has created a need for improved diagnostic and monitoring methods. Diabetes and its regulation have severe end of life consequences that tax available healthcare resources and burden economies worldwide as current techniques for treatment remain unsatisfactory.;Previously the Electronic Mosquito (a small "band-aid" like patch) was conceptualized and developed to overcome these deficits through the use of microsystems technology integrated with controlling electronics. The presented work endeavours to provide the e-Mosquito with feedback control over the depth of microneedle penetration in order to minimize painful interaction with nerve tissue. Current blood glucose monitors make extensive use of glucose oxidase to quantify glucose within the collected sample; the work herein examines the possibility of implementing a purely electrical impedance based sensor for blood glucose analysis. The result of this work has been the production of a macromodel which integrates these techniques into a single platform.