Explorations of the use of Olanzapine for Management of Chemotherapy-induced Nausea and Vomiting in Children.

摘要

Control of chemotherapy-induced nausea and vomiting (CINV) in children is sub-optimal and it continues to be a bothersome adverse effect. Effective new antiemetic interventions are required to improve CINV control. The purpose of the projects encompassed in this thesis was to explore the use of olanzapine for management of CINV in children. A systematic review of the safety of olanzapine in children was completed to determine if adverse effects would preclude evaluation of its use for CINV. A retrospective review summarized its efficacy and safety in children with cancer. Based on the results of these projects, olanzapine appears to be safe for use in children with cancer and improved CIV control rates may be achievable when olanzapine is added to antiemetics consistent with clinical practice guidelines. Overall, olanzapine appears to be a promising intervention for management of CINV in children and future prospective, controlled trials evaluating its use are warranted.