Pharmacokinetics, tissue depletion, target animal safety and live animal swab test accuracy after administration of long-acting oxytetracycline at double the label dose in healthy calves.

摘要

xytetracycline (OTC) concentrations in plasma and tissues, plasma pharmacokinetics, depletion from tissue, and toxicity, were studied in 30 healthy calves after IM administration of a long-acting OTC preparation (40 mg/kg of body weight) at double the label dose (20 mg/kg). Plasma OTC concentration increased rapidly after drug administration, and by 2 hours, mean (;The live animal swab test (LAST) was compared with quantitative oxytetracycline (OTC) assay of urine samples and tissue specimens to determine the accuracy of the LAST in detecting OTC in bovine urine and predicting violative residues in tissues. When urine OTC concentration was