Surface-based characterization of intra-surgical brain deformations in image-guided surgery .

摘要

Image-guided surgery (IGS) is a technique for localizing anatomical structures on the basis of volumetric image data and for determining the optimal surgical path to reach these structures, by the means of a localization device, or probe, whose position is tracked over time. The usefulness of this technology hinges on the accuracy of the transformation between the image volume and the space occupied by the patient anatomy and spanned by the probe. Unfortunately, in neurosurgery this transformation can be degraded by intra-surgical brain shift, which often measures more than 10 mm and can exceed 25 mm. I propose a method for characterizing brain shift that is based on non-rigid surface registration, and can be combined with a constitutively realistic finite element approach for volumetric displacement estimation.; The proposed registration method integrates in a unified framework all of the stages required to estimate the movement of the cortical surface in the operating room: model-based segmentation of the pre-operative brain surface in magnetic resonance image data, range-sensing of the cortex in the OR, range-MR rigid transformation computation, and range-based non-rigid brain motion estimation. The brain segmentation technique is an adaptation of the surface evolution model. Its convergence to the brain boundary is the result of a speed term restricted to white and grey matter voxels made explicit by a classifier, and the final result is post-processed to yield a Closest Point Map of the brain surface in MR space. In turn, this Closest Point Map is used to produce the homologous pairs required to determine a highly efficient, 2D spline-based, Iterative Closest Point (ICP) non-rigid surface registration. The baseline for computing intra-operative brain displacement, as well as the initial starting point of the non-rigid ICP registration, is determined by a very good rigid range-MR transformation, produced by a simple procedure for relating the range coordinate system to that of the probe, and ultimately to that of the MR volume.; Finally, this thesis also features a review of image guidance for brain surgery, a published survey of anatomical surface registration, and a literature review of biomechanical modeling of brain tissue.