Determination of trace elements levels in human plasma and radiated mice tongue by inductively coupled plasma-mass spectrometry (ICP-QMS).

摘要

An analytical method that uses a minimum150 iL of human plasma samples for the trace elements Fe, Cu, Zn, Mg and ultratrace elements Mn, Co, Cd, Pb was developed. The method was evaluated using both high resolution sector field (ICP-SFMS) and quadrupole (ICP-QMS) inductively coupled plasma mass spectrometry to analyze trace elements in SeronormRTM quality control materials. This analytical method was used to analyze 1900 plasma samples for trace elements and ultra-trace elements in a blinded study conducted by the National Cancer Institute (NCI). Plasma samples are from control individuals and esophageal cancer patients from Iran and China, which were collected 1980s and archived by NCI. Because of limited sample information was exposed, no statistical analysis was applied. Most trace and ultratrace elements were close to reference values. Possible reasons of elevated Mn and Pb levels in the plasma samples were investigated.