The Development of A Three-Dimensional Fast Spin-Echo Based MRI-Fricke-infused Gel Dosimetry

摘要

MRI-Fricke-infused gel dosimetry is a useful tool for the conformal and three-dimensional absorbed radiation dose measurements[1, 2]. However, measurement accuracy may be seriously degraded due to ferric ion diffusion over prolonged MR imaging time period,a detrimental factor faced especially for three-dimensional dosimetry cases where conventional MR data acquisition would take hoursto complete. In order to avoid this undesirable degradation, it is imperative to switch to fast MRI scanning methods. In this study, wederive the dose-response characteristics and examine the optimal parameters using three-dimensional fast spin echo (3D-FSE) methodto do 3D gel dosimetry. We showed that both ferric ion diffusion and partial volume effects could be effectively reduced thusrendering a more effectual approach to conduct 3D gel dosimetry.