MODELLING NORMAL PRESSURE HYDROCEPHALUS AS A 'TWO-HIT DISEASE USING MULTIPLE-NETWORK POROELASTIC THEORY

摘要

The evolution of many cerebral diseases such as Alzheimer's and Parkinson's Disease, Hydrocephalus, Cerebral Oedema, Stroke, and Tumour are strongly correlated to a change in the transport properties of fluid in the brain. This research pro-poses a novel application of Multiple-Network Poroelastic The-ory (MPET) to investigate cerebral hydrodynamics through a de-tailed investigation of multiscalar, spatio-temporal transport of fluid between the cerebral blood, cerebrospinal fluid (CSF) and brain parenchyma. Specifically, MPET is used to interrogate the clinical markers of Normal Pressure Hydrocephalus (nph).