Characterizing tumor changes during neoadjuvant treatment of locally advanced breast cancer patients (LABC) using dynamicenhanced magnetic resonance imaging (DE-MRI)

摘要

200). During the HT treatments temperatures in the breast were measured invasively via a catheterinserted under CT guidance. Although minimum sampled temperatures give a crude indication of the temperaturedistribution, several thermal dose metrics were calculated for each of the HT fractions (e.g. T90, T50, T10). As expected,tumors that were more vascularized (i.e. higher WiP) heated less than tumors with low WiP, a degree on average. Theadjuvant treatment also changed the shape and inhomogeneity of the perfusion/permeability maps, with dramaticchanges after the first fraction in responders. The correlation between the thermal metrics and pathological response willbe discussed, as well as possible correlation with other tumor physiology parameters. In conclusion, the Gd-enhancementanalysis of DE-MRI images is able to generate information related to the tumor vascularity, permeability and cellularitythat can correlate with the tumor’s response to the neoadjuvant treatment in general, and to HT in particular. Worksupported by a grant from the NCI CA42745.