The Use of pH-sensitive Poly(propylacrylic acid) Polymers to Enhance the Delivery of Antigens for Therapeutic Vaccination

机译：pH敏感的聚（丙稀丙烯酸）聚合物在治疗性疫苗接种中增强抗原传递的用途

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It is possible to obtain and characterizeprotein/peptide-p(PAAc) conjugates that are able todisrupt membranes in a pH and concentration-dependentmanner, as evidenced by RBC hemolysis. Furthermore,conjugation of the antigens to p(PAAc) can significantlyincrease class I antigen presentation and cytotoxic T-cellactivation.

机译：如RBC溶血所证明的那样，有可能获得并表征能够破坏pH和浓度依赖性的膜的蛋白质/肽-p（PAAc）缀合物。此外，抗原与p（PAAc）的缀合可以显着增加I类抗原呈递和细胞毒性T细胞活化。

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《Society for Biomaterials Transaction Annual Meeting vol.29 pt.1》|2006年|44|共1页
会议地点 Pittsburgh,PA(US)
作者
Suzanne Flanary; Jared R. Kirkham; Patrick S. Stayton; Allan S. Hoffman;
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University of Washington Seattle WA;

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1. Antigen Delivery with Poly(Propylacrylic Acid)Conjugation Enhances MHC-1 Presentation and T-Cell Activation [J] . Suzanne Flanary, Allan S.Hoffman, Patrick S.Stayton Bioconjugate Chemistry . 2009,第2期

机译：带有聚（丙丙烯酸）缀合物的抗原递送增强了MHC-1的呈递和T细胞活化
2. Poly(2‐propylacrylic acid)/poly(lactic‐co‐glycolic acid) blend microparticles as a targeted antigen delivery system to direct either CD4+ or CD8+ T cell activation [J] . Lirong Yang, Evelyn Bracho‐Sanchez, Lawrence P. Fernando, Bioengineering & Translational Medicine . 2017,第2期

机译：聚（2-丙基丙烯酸）/聚（乳酸-乙醇酸）共混微粒作为靶向抗原传递系统，可引导CD4 +或CD8 + T细胞活化
3. Poly(propylacrylic acid) Enhances Cationic Lipid-Mediated Delivery of Antisense Oligonucleotides [J] . Li Kim Lee, Charity L.Williams, David Devore, Biomacromolecules . 2006,第5期

机译：聚（丙丙烯酸）增强阳离子脂质介导的反义寡核苷酸的传递。
4. The Use of pH-sensitive Poly(propylacrylic acid) Polymers to Enhance the Delivery of Antigens for Therapeutic Vaccination [C] . Suzanne Flanary, Jared R. Kirkham, Patrick S. Stayton, Society for Biomaterials Transaction Annual Meeting vol.29 pt.1; 20060426-29; Pittsburgh,PA(US) . 2006

机译：pH敏感的聚（丙稀丙烯酸）聚合物在治疗性疫苗接种中增强抗原传递的用途
5. Therapeutic vaccination with ribonucleic acids encoding tumor/self antigens and a cytokine adjuvant in a transgenic murine model of prostatic carcinoma. [D] . Hess, Paul Robert. 2002

机译：在前列腺癌的转基因鼠模型中，用编码肿瘤/自身抗原的核糖核酸和细胞因子佐剂进行治疗性疫苗接种。
6. Antigen Delivery with Poly(Propylacrylic Acid) Conjugation Enhances MHC-1 Presentation and T-Cell Activation [O] . Suzanne Flanary, Allan S. Hoffman, Patrick S. Stayton -1

机译：带有聚（丙基丙烯酸）结合的抗原传递增强了MHC-1的呈递和T细胞活化
7. Poly(propylacrylic acid) Enhances Cationic Lipid-Mediated Delivery of Antisense Oligonucleotides [O] . Li Kim Lee, Charity L. Williams, David Devore, 2006

机译：聚（丙烯酸）增强阳离子脂质介导的反义寡核苷酸的递送

The Use of pH-sensitive Poly(propylacrylic acid) Polymers to Enhance the Delivery of Antigens for Therapeutic Vaccination

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