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Anti-inflammatory biocompatible dexamethasone-loaded porous microparticles for acute lung injury

机译:抗炎生物相容性地塞米松负载多孔微粒治疗急性肺损伤

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We synthesized PVAX which was designed to react with H_2O_2 and release antioxidant and anti-inflammatory vanillyl alcohol during its hydrolytic degradation. Dexamethasone-loaded porous PVAX microparticles included peroxalate linkage scavenged H_2O_2 and inhibited the generation of TNF-a. We anticipate that the administration of DEX-loaded PVAX porous microparticles are useful in the treatment of pulmonary inflammatory diseases.
机译:我们合成了旨在与H_2O_2反应并在其水解降解过程中释放出抗氧化剂和消炎香兰醇的PVAX。地塞米松负载的多孔PVAX微粒包含过草酸盐键清除了H_2O_2,并抑制了TNF-α的产生。我们预期DEX加载的PVAX多孔微粒的管理可用于治疗肺炎性疾病。

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