In Situ Forming Drug Delivery Scaffold for Treating Avascular Necrosis of the Femoral Head

摘要

The difference in release kinetics between drugs is likely due to their different aqueous solubilities as well as PBAE chemical properties, indicating that scaffolds are capable of providing multiple drug release with tunable kinetics. By increasing HA content, scaffold compressive modulus can be increased to provide additional mechanical support for diseased bone, which may prevent structural collapse that leads to permanent damage in AVNFH. Scaffold porosity is important to allow new bone ingrowth, and scaffolds will degrade over a period of months to accommodate tissue regeneration.