Hepatodifferentiation Of Cadherin Expressing Embryonic Stem Cells Within A Microengineered Organotypic Model

摘要

The presence of direct cell-cell contact augmented the presence of the late hepatic marker, glucose-6-phosphatase in cadherin-expressing cells. Also, there was enhanced albumin-based differentiation at the direct stem cell/hepatocyte interface, indicating that murine ES cells derived differentiating cues from micro-scale islands of mature liver cells. In the future, these cadherin based interactions will be promoted via optimized microscale coculture configurations.