Fibronectin Behaviour and Cellular Response to Nanostructured Surfaces

摘要

Conformation of attached proteins is critical for biological function. Creation of surface nanotopography using a range of colloidal silica sizes leads to a distinctive cellular response. The surface treatment is able to inhibit the spreading and proliferation of cells, which are round in morphology and weakly attached to the substrates, but remain viable. This is attributed to a change in the conformation of fibronectin leading to the cellular adhesion site being no longer available.