Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation

摘要

In this study, we have shown that Jagged-1 can be immobilized to a surface, the immobilized Jagged-1 is active, and the presentation of this ligand results in enhanced differentiation and stratification of the epithelial stem cells. Harnessing cell-cell signaling pathways, such as Notch, for surface modification represents a powerful and previously untapped means to control cell behavior at the biomaterial interface.