Intramuscular Bone Formation Evaluation of Different Collagen/TCP Scaffolds in Canine Paraspinal Muscle

摘要

In this study we have demonstrated a novel collagen/TCP scaffold that is able to induce intramuscular bone formation without the addition of any bone marrow or growth factors. To our knowledge, this is the first reported instance of a collagen/TCP composite with this property. While it is known that the submicron morphology properties of the TCP granules need to be within a critical range, this study also showed that the structure of the collagen also specific, since one formulation inhibited bone formation to a far greater extent than another.