Dissolution behavior cannot be a sole indicator for oral absorption of nanocrystals using nimodipine as a model drug

摘要

Purpose: To investigate the relationships between dissolution and pharmacokinetics for nimodipine nanocrystals and Nimotop, and then to explore whether dissolution behavior could be the only evaluative criteria for oral bioavailability of nanocrystals. Methods: With Nimotop? as a reference, the dissolution rates were evaluated using a paddle method and the pharmacokinetic study was undertaken in beagle dogs. Results: The nanocrystals exhibited lower dissolution patterns than Nimotop?. The bioavailability of the nanocrystals (150 and 850 nm) was equivalent, about 2.6-fold higher than Nimotop?. Conclusion: Dissolution performance couldn't be the only evaluative index for preparations based on nanocrystal delivery platform.