A rising temperature kinetic model to describe complex reaction kinetics of a drug: procainamide hydrochloride

摘要

The drug Procainamide Hydrochloride (NH_2C_6H_4CONHCH_2CH_2N(CH_2CH_3)_2 HCl) was studied using a simultaneous thermo gravimetric-differential thermal analysis unit (TG-DTA) in an atmosphere of nitrogen. The study covered the range of temperature from ambient to 800 deg C. The DTA showed a melting point at 169deg C followed by a two stage endothermic transition. The TG/DTG plots showed clearly this two stage transition. A kinetic analysis of the two stages was attempted. The best fit appeared to be a first order mechanism for both stages. It also was noted that the values of E_(act) varied as the reaction progressed. Supportive evidence regarding the study was obtained from a range of other physio-chemical measurements.