Mining the Common Facts in Cancer : Reliability of Protein Expression in Breast Cancer and Brain Tumor

摘要

The common biological targets could provide and facilitate a useful avenue in cancer research. The main aim of this study was to find the nature of protein expression of Ki67 labeling index, cyclin E, CDC25A, and ATM by inmmunofluorescence assay in breast cancer and brain tumor.Ki67-index behaves more harmonic with CDC25A, and cyclin E is less expressed, either in breast cancer, or in brain tumor. Comparison of the ATM expression in these two different malignancies, revealed the visibility in the limited cell numbers of either malignancies. It could be concluded that the expression of ATM-gene at protein level, is characterized with a low level and was also accompanied by the specific alteration at molecular level. Such characteristics could be considered as a common target for being traced either in breast cancer tissues or in brain tumors. A harmonic support at protein- and molecular terriiorics could reflect a common fact in two completely different cancers.