An Integral Approach To Solid State Issues, Highlighting High Throughput Screening

摘要

Solid state properties of pharmaceutical substances have a huge impact in thernwhole development process of a drug. In a very early phase, the most suitable salt formrnhas to be selected optimizing properties such as solubility, hygroscopicity and stability.rnThen allrnrelevant polymorphs and solvates have to be identified, methods to determine polymorphrnpurity have to be established, efficient crystallization methods for that particularrnpolymorph have to be developed etc. The identification of all relevant solid forms, i.e.rnpolymorph screening, is often one of the most laborious and time-consuming steps, and itrnis therefore very attractive to speed up that process using high throughput methods. Inrnthis presentation the development of a powerful high throughput screening system usingrnRaman microscopy as a detection method for the polymorphic form will be discussed.rnWe will highlight important issues in connection with efficient high throughput screeningrnand will discuss practical examples.