Research on the Regulatory Factors of Skeletal Muscle Mitochondrial Biogenesis in Exercise

摘要

Exercise can mobilize the cell signal induced mitochondrial biogenesis, it can not only increase the volume of mitochondrial effectively, improving the capacity of provide energy for ATP and delaying fatigue occurs. But also prevent muscle function decreased by age-related degenerative changes. Cell signal of mobilization activate certain protein gene transcription, and these proteins get into the mitochondria firstly as a single subunit enzyme activating mitochondrial DNA gene expression, the formation process of molecules is complex. It don't exercise for long time with age growing, the channel of mitochondria damaged in muscle which leading to aerobic mitochondrial dysfunction and the increased trend apoptosis of mitochondrial regulation can lead to decrease muscle function. By choosing the right way of exercise, it can improve the metabolic dysfunction and maintain muscle mass.