Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy

摘要

In this retrospective cohort study, we examine the hypothesis that baseline oxygen saturation (SO_2%) in contralateral normal tissue can be a quantitative measurement for predicting tumor response to neoadjuvant chemotherapy (NAC). Using our dynamic custom-built dual breast dynamic diffuse optical tomography (DOT) imager, we reconstructed SO_2% measurement concentration for 12 stage II or III breast cancer patients. Six patients achieved pCR (RCB-0) and the other half had extensive residual disease (RCB-III). Baseline SO_2% in contralateral normal tissue was statistically significantly higher in RCB-III subjects than in pCR (p = 0.025). From ROC analyses, baseline SO_2% in contralateral normal breast tissue was able to discriminate pCR from RCB-III patients (AUC 0.889) with sensitivity and specificity of 83%.