Effects of combined Xenon and Hypothermia on Cerebral Blood Flow and Oxygen Consumption in Newborn Piglets measured with a Time-Resolved Near-Infrared Technique

摘要

Mild hypothermia (HT), in which the brain is cooled to 32-33℃, has been shown to be neuroprotective for neurological emergencies such as head trauma and neonatal asphyxia. Xenon (Xe), a scarce and expensive anesthetic gas, has also shown great promise as a neuroprotectant, particularly when combined with HT. The purpose of the present study was to investigate the combined effect of Xe and HT on the cerebral metabolic rate of oxygen (CMRO_2) and cerebral blood flow (CBF). A closed circuit re-breathing system was used to deliver the Xe in order to make the treatment efficient and economical. A bolus-tracking method using indocyanine green (ICG) as a flow tracer with time-resolved near-infrared (TR-NIR) technique was used to measure CBF and CMRO_2 in newborn piglets.