THE SYNTHESIS AND AQUEOUS SOLUTION PROPERTIES OF FUNCTIONALIZED AND THERMO-RESPONSIVE POLY (D,L-LACTIDE) /POLYETHER BLOCK COPOLYMERS

摘要

Novel tri- and pentablock copolymers comprised of hydrophobic PL and hydrophilic polyoxiranes were synthesized mainly with the aid of anionic polymerization. PG-PEO-PL copolymers formed stable functionalized micelles in aqueous media, while PL-PEO-PPO-PEO-PL solutions clouded, and cmc values were affected by the temperature. The hydrophilic-hydrophobic balance may be effectively varied by altering the number of L units. The copolymers described here are candidates for carriers in drug delivery systems. The hydroxyl - functionalized PG block opens an attractive approach for attachment of drug-targeting agents on PG-PEO-PL micelle surface. Thermosensitive PL-PEO-PPO-PEO-PL micelles can participate in immobilizing of two drugs - one in the PPO domains and the other - in PL core.