Dynamic Changes of Cytokines in Patients with SIRS and the Effect of Chinese Herbal Medicine Intervention

摘要

To study the dynamic changes of serum pro-inflammatory cytokines and anti-inflammatory cytokines in patients with SIRS and to explore the effect of 912 compound, a Chinese herbal preparation for intervention. Methods: Forty patients with SIRS were randomly divided into 2 groups, 20 in the 912 group and 20 in the control group, and the levels of serum pre-inflammatory cytokines, including tumor necrosis factor a (TNF_α) and interleukin-6(IL-6) and anti-inflammatory cytokines, including soluble TNF-RI, IL-4 and IL-10 were measured before and after treatment by using enzyme-linked immunosorbent assay(ELISA). Results: The level of pro-and anti-inflammatory cytokines were all elevated in various degrees at the early stage of SIRS, particularly obvious in IL-6, Stnf-RI, IL-4 and IL-10 and the elevations of the two were basically parallel. The TNF_α, IL-6 and Stnf-RI were positively related with APACHE Ⅲ scoring, The level of inflammatory cytokines reduced to a different extent in accord with the improvement of condition after treatment, the levels of TNF_α, IL-6, and IL-10 lowered more significantly in the 912 group than those in the control group(P<0.05). Conclusions: pro-inflammatory and anti-inflammatory cytokines play important roles in SIRS, they were important indexes for evaluating severity of infectious diseases. The Chinese herbal preparation 912 compound could reduce the blood levels of LPS, TNF_α, IL-6, IL-10 and prevent the decrease of Stnf-RI so as to promote the recovery of patients.