Computational Biomechanics of Bone Adaptation by Remodeling

摘要

In bone remodeling, a variety of mechanical and biochemical signaling occurs among osteoclasts and osteoblasts, which are responsible for bone resorption and formation, and osteocytes, which are believed to have a mechanosensing function. Biomechanics research incorporating mathematical modeling and computer simulations is being conducted in order to understand the functional adaptation of bone structure by remodeling that can be observed at a macroscopic level resulted from the complex interaction among these signals at molecular and cellular levels.