ENVIRONMENTAL BEHAVIER AND IN VIBO DISTRIBUTION OF HYDROXYLATED PCB METABOLITES(HO-PCB) IN GREAT CORMORANT(PHALACROCORAX CARBO)

摘要

Introduction It is well known that polychlorinated biphenyls (PCBs) which widespread environmental contaminant is metabolized to hydroxylated polychlorinated biphenyls (HO-PCBs) by cytochrome P450 (CYP) enzyme-mediated oxidation. A large number of investigations for the levels of HO-PCBs in blood compartment (mainly plasma) of human and wildlife have been reported as described in recent two reviews. It is speculated that the residue profile of HO-PCBs is vary among species due to some factors such as the differences in metabolic capacity and affinity of binding protein. Because the omnivorous and piscivorous avian species which are the top predator of food chain tend to bioaccumulate PCBs, the high exposure of HO-PCBs by metabolism of PCBs is quite possible.