PPPS-2013: Mammalian cell activities are modulated by non-thermal atmospheric pressure plasma

摘要

Non-thermal atmospheric pressure plasma consists of partially ionized gas and contains a range of reactive species including biological active ROS and RNS. There are numerous future applications planned in medicine, e.g. blood coagulation, disinfection and wound care. Recently it has been shown that plasma treatment can have lethal effects on bacteria, whereas eukaryotic cells can be promoted to grow and proliferate. The aim of this study was to investigate the impact of non-thermal plasma on the stimulation of mammalian cells. The cells were treated with the atmospheric pressure plasma jet kINPen09 and it was shown that the effects were dependent on treatment time. While long treatment induced apoptosis, short time plasma treatment increased the proliferation. Therefore the underlying processes needed to be identified in order to modulate the plasmas for future applications.