Anti-tumor effects and mechanism of polysaccharides from sweet potato

摘要

In this paper, a study on anti-tumor effects and mechanism of Polysaccharides from sweet potato(PSP)has been made. Experiments in vivo and in vitro show that PSP inhibit tumor cells fissiparity directly .The K562 Mammary Carcinoma cells and Hca-f solid tumor cells with the treatment of PSP have been greatly inhibited. The inhibition rate reach to 75%(P<0.01 )while PSP does little harm to the natural cells (FC, flbroblast cell). In the mean time,immune defence system in vivo is activated.Compared with the control,lymphocyte transformation rate increase noticeably as well as thymus index and spleen index (P<0.01 ). It indicate that PSP can activate immune defence reaction in vivo.The anti-tumorm mechanism of PSP is : PSP bind specifically to tumor cell receptor and this kind of binding could affect intracellular physiological function of the tumor. Then immune defense reaction is activated to defence tumor cells.