Comparison of Employing WI-38 and NIH/3T3 Cells for Evaluation of Chemotherapeutic Index and Growth Inhibition Values for Pancreatic Cancer Cell Lines for Group IVB Metallocene and Group VA Metal-Containing Polymers Derived from Glycyrrhetinic Acid, 3,5-Pyridine-dicarboxylic Acid, and Histamine

摘要

Pancreatic cancer afflicts close to 32,000 individuals each year in the United States and 168,000 worldwide, and nearly all patients die from the ravages of their disease within 3 to 6 months after detection. It is the fourth leading cause of cancer death worldwide behind lung (1.3 million deaths/year), stomach (1 million deaths/year), and liver (660,000 deaths/year). Treatment of pancreatic cancer is rarely successful as this disease typically metastasizes prior to detection. There is no chemotherapy for metastasized pancreatic cancer. More organotin compounds are available commercially than any other metal-containing organometallics.1,2 Further, more organotin compounds have undergone testing as potential anticancer agents than any other single group of compounds.2,3 While much of our recent effort has involved organotin-containing monomers and polymers, we have also been evaluating other metal-containing polymers and monomers.2-43 Much of this effort involved coupling organotin moieties with molecules that have known biological activities attempting to couple the biological activities of both the organotin and other metal-containing moiety and biologically active second molecules. The current effort is a continuation of this but employing other metal-containing materials.