Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions

摘要

Cardiovascular complication is a major health concern for diabetic patients. Elevated blood sugar levels lead to theformation of advanced glycation end products (AGEs), which are implicated in diabetic pathogenesis. In this study, weinvestigate the effect of prolonged exposure to elevated sugar level by studying the combined effect of diffusion andglycation rate in arteries from different commonly-consumed simple sugars. Since some AGEs are autofluorescent, wewill perform multiphoton autofluorescence imaging to quantify the rates of fluorescent AGEs formation in elastic fibersand collagen fibers. Cross-section imaging of arteries and spatial and temporal profiles of autofluorescence of the bloodvessel will be investigated.