Research Progress on the Relationship Between Interleukins Gene Polymorphism and Type 2 Diabetes

摘要

Inflammation plays a significant role in the etiology and pathogenesis of type 2 diabetes mellitus (T2DM). Many single nucleotide polymorphisms (SNPs) in various genes including inflammatory cytokines have been reported as a risk for T2DM. Interleukins (IL) such as IL - 6, IL - 10, IL - 18 and IL - 1 are strongly associates with increased risk of type 2 diabetes. This review will summarize and recommend studies that investigated associations between Interleukins gene polymorphism and T2DM.