Oleanolic acid on SAMP8 mice in vivo experimental intervention study

摘要

Objective: To study the application of Chinese herbs (Ligustrum lucidum) monomer oleanolic acid on Alzheimer's disease (AD) model mice cognitive learning ability, and E2 in vivo, Ach, TSH, interferon levels, and to explore the relationship among them. Methods:18 24-week-old mice (rapidly aging SMP8) were randomly divided into oleanolic acid group, the placebo group and SMP8 control group, and the other 6 selected mice as a homologous normal aging SAMR1 control group, the use of irrigation stomach after 4 weeks of drug intervention methods for water maze test(Morris maze) and biochemical testing of serum E2, Ach, TSH, IFN-concentration changes. Results: Oleanolic acid can effectively improve the Cognitive learning ability of the SMP8 mice, and impact the levels of E2, Ach, TSH, interferon (P <0.05). Conclusion: Oleanolic acid can be adjusted SAMP8 mice E2, Ach, TSH, interferon levels, and improve Alzheimer's mice cognitive learning ability, to achieve the prevention and treatment of senile dementia of the results.