pH-triggered Reversible Morphological Inversion of Orthogonally-addressable Poly(3-acrylamidophenylboronic acid)-block-poly(acrylamidoethylamine) Micelles and Their Shell Crosslinked Nanoparticles

摘要

During the past decade, “smart” or “intelligent” stimuli-responsive polymers have attracted increasing research interest because of the change of their morphologies, surface charges and properties upon external stimuli, such as pH, temperature, light, salt concentration and the combination of these parameters. Nanoscopic materials derived from stimuli-responsive block copolymers have broad potential for applications in a variety of areas, including switches and sensors, drug delivery vehicles, diagnostics and antifouling coatings. Among several stimuli-responsive polymers, those containing boronic acid-functionalized repeat units are of particular interest because of their potential applications as sensor materials, self-regulated insulin delivery systems, and flame-retardant materials.