Compatibility between Paclitaxel and Polymer Carrier

摘要

Several polymer-based drug delivery systems are being developed to enhance the extremely low water-solubility of paclitaxel (PTX). It is believed that there is a positive correlation between the compatibility of polymer-drug and the solubilization. In recent years, solubility parameters for polymer and drug were used to evaluate degree of compatibility between a drug and a polymer, which were measured using various experimental methods or estimated using the group contribution menthod (GCM). In this study, degree of compatibility between PTX and polymers were estimated by molar free energy of mixing (ΔG_(mix)) that was calculated through computer simulation. It is found that the degree of compatibility is: PTX-PTRP > PTX-PLBG > PTX-PLGA > PTX-PCL > PTX-PLA. It has been demonstrated that the result of this study is in accord with the Similar Dissolve Mutually Theory.