Nano-Sized Carriers for Carbon Monoxide Releasing Molecules

摘要

Nanoparticles (NPs) can not only act as scaffolds, but also can be used to trigger carbon monoxide (CO) release.The very elegant light-induced CO release can so far only be used in treatment of surface tissues as the light useddoes not penetrate deeply into tissues. Here we report on our on-going work to modify the CO release characteristicsby incorporation into nano-scale composites. Different biocompatible nanoparticles were decorated by CO-releasingmolecules (CORMs). For efficient decoration we developed a L-DOPA (Levodopa, L-3,4-dihydroxyphenylalanine)derived CORM-3 analog. The CORM-functionalized NPs show temperature and pH-dependent CO release.