Enhanceing Antitumor Effect of Adriamycin Nanoparticle -Lipiodol Emulsion by Pretreating Tumor Cells with Diethyldithiocarbamate

摘要

The antitumor effect of adriamycin nanoparticle-lipiodol emulsion combined with Diethyldithiocarbamate (DDC) was studied. SD rats with carcinoma were divided to six groups and respectively treated by delivering saline, adriamycin, adriamycin nanoparticle-lipiodol emulsion, adriamycin liposome-lipiodol emulsion, DDC and adriamycin nanoparticle-lipiodol emulsion, DDC and adriamycin Ltposome-lipiodol emulsion. The volume of every tumor in rats, tumors growth rate(G%) and life prolong rate PL% in six groups were determined. It was found the value of the IC_(50)(ug/ml) of adriamycin was reduced from 18.40 to 0.74 for the resistant cells SGC7901/CVR, and from 4.00 to 0.32 for the sensitive cells SGC7901/WT by pretreating the tumor cells with DDC. The tumors growth rate(G%) and life prolong rate PL% in rats increased significantly(P<0.05) in the groups DDC pretreated than adriamycin nanoparticle-lipiodol or adriamycin Liposome-lipiodol emulsion groups. It is conformed the antitumor effect of adriamycin can be enhanced by inhibiting the superoxide dismutase (SOD) in tumor cells with DDC.