Endothelial dysfunction late after coronary angioplasty: a quantitative coronary angiographic study in patients without restenosis

摘要

Endothelial function after coronary angioplasty (PTCA) has been evaluated by quantitative coronary angiography in 18 patients with no evidence of significant restenosis at routine angiographic followup. Increasing doses of acetylcholine (Ach) were infused in the dilated coronary artery, followed by a 250 mu g bolus of nitroglycerin. Total PTCA segments examined were 21. The PTCA treated vessels showed abnormal response to Ach in all their segments. This vasoconstriction was more evident not only at the site of previous maximal stenosis but also in normal vascular sites stretched by the balloon. Vascular response to Ach suggests that endothelial function of neointima is impaired late after PTCA.