Cerium Oxide Nanoparticles Protect Against MPTP-Induced Dopaminergic Neurodegeneration In A Mouse Model For Parkinson's Disease

摘要

Cerium oxide nanoparticles (CeONP) are regenerative free radical scavengers that protect against oxidative stress. Previous work from this lab has shown that CeONP extend cell (mixed brain, neuronal, endothelial) and organism (Drosophila) longevity, protect against oxidative stress and free radical production, and are effective in tissue culture models of neurodegenerative disorders. Given that Parkinson's Disease (PD) is strongly associated with oxidative stress, and that CeONP act as free radical scavengers, it was hypothesized that CeONP may be a promising disease-modifying therapy for treatment of PD. Here, we demonstrate for the first time, that CeONP preserve striatal dopamine and protect dopaminergic neurons in the substantia nigra, in the MPTP-mouse model of Parkinson's Disease. This work demonstrates the potential for CeONP as a novel nanopharmaceutical for the treatment of neurodegenerative disorders.