Development of Bisphosphonate-functionalized Gelatin Nanoparticles for Application in Colloidal Hydrogels for Bone Regeneration

摘要

ALN was successfully conjugated to gelatin nanoparticles through covalent bonding to residual aldehyde groups resulting from nanoparticle crosslinking. Colloidal composite gels consisting of CaP and bisphosphonated gelatin nanoparticles show approximately similar self-healing behavior compared to composite gels consisting of CaP and unmodified gelatin nanoparticles. Future studies will evaluate the self-healing behavior of colloidal composite gels as a function of gelatin:CaP ratio.