Novel Elastic Mechanically Strong Nano-Composite Ceramic scaffold For Orthopaedic Applications

摘要

Developing highly bioactive, resorbable and mechanically strong scaffold for bone regeneration remains a challenge. Ceramic scaffolds shortfall has always been the tradeoff between sufficient mechanical strength and porosity, as well as the brittleness and bioactivity. We recently developed novel scaffolds through the controlled substitution of strontium (Sr) and zinc (Zn) into calcium silicate to form Sr-Ca_22nSi_207 referred to here as (Sr-HT). In the present study we successfully developed a new class of composite ceramic scaffold by coating Sr-HT scaffold by a nano-composite layer, consisting of 10% nano bioactive glass (BG) particles (to produce a highly bioactive composite scaffolds) and polycarbolactone (PCL) (to produce an elastic composite scaffold).