A Novel Method for Characterization of PEGylated Products in Biological Matrices

机译：一种新的生物学基质分子化产物的研究方法

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The methodology involved direct analysis of serum samples containing PEGylated products or treating serum samples of PEGpeptide with acetonitrile to precipitate interfering serum proteins, while maintaining the conjugated molecule of interest in the supernatant for analysis. The data demonstrated nearly complete recoveries at the range of 1 μg/ml or lower PEGylated products in serum. The data clearly revealed a clip at C-terminal of Arg18 residue in glucagon.

机译：该方法涉及含有聚乙二醇化产物的血清样品的直接分析，或用乙腈处理PEGPELDIELE的血清样品，以沉淀干扰血清蛋白，同时保持对上清液的缀合分子进行分析。数据显示在血清中的1μg/ ml或低聚乙二醇化产物的范围内几乎完全的回收率。数据清楚地揭示了胰高血糖素中Arg18残基的C末端的夹子。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2013年||共1页
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Qingyuan Liu; Michael R De Felippis; Lihua Huang;
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中图分类 TB994.5-53;
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4. A Novel Method for Characterization of PEGylated Products in Biological Matrices [C] . Qingyuan Liu, Michael R De Felippis, Lihua Huang American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

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A Novel Method for Characterization of PEGylated Products in Biological Matrices

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